Rebamipideisaquinolonederivativethatisclinicallyusedformucosalprotectioninthetreatmentofgastritisandulcers.RebamipideexhibitsantioxidativeactivityasarADIcalscavengerandinhibitsNSAID-inducedlipidperoxidation,alterationsinmitochondrialmembranepotential,andapoptosisinepithelialcells.
| CasNo. | 90098-04-7 |
|---|---|
| Purity | ≥98% |
| Formula | C19H15ClN2O4 |
| FormulaWt. | 370.79 |
| ChemicalName | α-[(4-Chlorobenzoyl)-amino]-1,2-dihydro-2-oxo-4-quinolinepropanoicacid |
| IUPACName | 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoicacid |
| Synonym | Proamipide;OPC-12759;Mucosta |
| MeltingPoint | 288-290°C(dec) |
| Solubility | Solubleindimethyl-formamide,DMSO(74mg/mL).Slightlysolubleinwater,methanolandethanol. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | R1806MSDSPDF |
|---|---|
| InfoSheet | R1806InfoSheetPDF |
NaganoY,MatsuiH,MuramatsuM,etal.Rebamipidesignificantlyinhibitsindomethacin-inducedmitochondrialdamage,lipidperoxidation,andapoptosisingastricepithelialRGM-1cells.DigDisSci.2005Oct;50Suppl1:S76-83.PMID:16184425.
ArakawaT,KobayashiK,YoshikawaT,etal.Rebamipide:overviewofitsmechanismsofactionandefficacyinmucosalprotectionandulcerhealing.DigDisSci.1998Sep;43(9Suppl):5S-13S.PMID:9753220.
ArakawaT,WatanabeT,FukudaT,etal.Rebamipide,novelprostaglandin-induceraccelerateshealingandreducesrelapseofaceticacid-inducedratgastriculcer.Comparisonwithcimetidine.DigDisSci.1995Nov;40(11):2469-72.PMID:7587834.
