Resiniferonol-9,13,14-orthophenylacetate(ROPA)isaditerpenevanilloidderivativeofresiniferatoxin.Invitro,ROPAinducesG1/Sphasecellcyclearrest,downregulatesexpressionofcyclinD1,upregulatesexpressionofp21,andinducesactivationofERK1/2,JNK1/2,andMAPKs.ROPAmayactivatePKC,promotingcarcinogenesisandactingasatumorpromoter.
| CasNo. | 57852-42-3 |
|---|---|
| Purity | ≥98% |
| Formula | C28H32O6 |
| FormulaWt. | 464.56 |
| ChemicalName | Daphnetoxin,6,7-deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)- |
| Synonym | ROPA;ROP |
| Solubility | SolubleinDMSOorethanol. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | R1775InfoSheetPDF |
|---|
FreyMR,ClarkJA,BatemanNW,etal.Cellcycle-andproteinkinaseC-specificeffectsofresiniferatoxinandresiniferonol9,13,14-ortho-phenylacetateinintestinalepithelialcells.BiochemPharmacol.2004May15;67(10):1873-86.PMID:15130764.
GeigesD,MeyerT,MarteB,etal.ActivationofproteinkinaseCsubtypesalpha,gamma,delta,epsilon,zeta,andetabytumor-promotingandnontumor-promotingagents.BiochemPharmacol.1997Mar21;53(6):865-75.PMID:9113106.
