Resiniferonol-9,13,14-orthophenyl acetate (ROPA) is a diterpene vanilloid derivative of resiniferatoxin. In vitro, ROPA induces G1/S phase cell cycle arrest, downregulates expression of cyclin D1, upregulates expression of p21, and induces activation of ERK1/2, JNK1/2, and MAPKs. ROPA may activate PKC, promoting carcinogenesis and acting as a tumor promoter.
| Cas No. | 57852-42-3 |
|---|---|
| Purity | ≥98% |
| Formula | C28H32O6 |
| Formula Wt. | 464.56 |
| Chemical Name | Daphnetoxin, 6,7-deepoxy-6,7-didehydro-5-deoxy- 21-dephenyl-21-(phenylmethyl)- |
| Synonym | ROPA; ROP |
| Solubility | Soluble in DMSO or ethanol. |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | R1775 Info Sheet PDF |
|---|
Frey MR, Clark JA, Bateman NW, et al. Cell cycle- and protein kinase C-specific effects of resiniferatoxin and resiniferonol 9,13,14-ortho-phenylacetate in intestinal epithelial cells. Biochem Pharmacol. 2004 May 15;67(10):1873-86. PMID: 15130764.
Geiges D, Meyer T, Marte B, et al. Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. Biochem Pharmacol. 1997 Mar 21;53(6):865-75. PMID: 9113106.
