Clobetasolisacorticosteroidthatactivatesglucocorticoidreceptorsandexhibitsanti-inflammatoryandimmunosuppressiveactivities.Clobetasolisclinicallyusedtotreateczema,psoriasis,contactdermatitis,andseveralautoimmunediseases.ClobetasolinhibitsTNF-α-andCD40L-inducedactivationofNF-κBinvitro.
| CasNo. | 25122-46-7 |
|---|---|
| Purity | ≥98% |
| Formula | C25H32ClFO5 |
| FormulaWt. | 466.98 |
| ChemicalName | (11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione |
| IUPACName | [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]propanoate |
| Synonym | Clobesol;Dermoval;Dermovate;Dermoxin;Temovate |
| MeltingPoint | 195.5-197°C |
| Solubility | Solubleinacetoneormethylenedichloride. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C4659InfoSheetPDF |
|---|
CechinSR,BuchwaldP.EffectsofrepresentativeglucocorticoidsonTNFα-andCD40L-inducedNF-κBactivationinsensorcells.Steroids.2014Jul;85:36-43.PMID:24747770.
LenaneP,MacarthurC,ParkinPC,etal.Clobetasolpropionate,0.05%,vshydrocortisone,1%,foralopeciaareatainchildren:arandomizedclinicaltrial.JAMADermatol.2014Jan;150(1):47-50.PMID:24226568.
