Cyclophosphamideisanitrogenmustardthatactsasanalkylator,addingalkylgroupstotheN7nitrogenofguaninebases;thisinhibitsDNArepairandreplication.Cyclophosphamideexhibitsanticancerchemotherapeuticandimmunomodulatoryactivities.ThiscompoundisonecomponentintheCHOPchemotherapyregimen.Cyclophosphamideisclinicallyusedtotreatvariouscancers,graft-versus-hostdisease(GvHD),andautoimmunediseasessuchasmultiplesclerosis,rheumatoidarthritis,andsystemiclupuserythematous(SLE).
| CasNo. | 6055-19-2 |
|---|---|
| Purity | ≥98% |
| Formula | C7H15Cl2N2O2P•H2O |
| FormulaWt. | 279.10 |
| ChemicalName | N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-ox-azaphosphorin-2-amine2oxidemonohydrate |
| IUPACName | N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine;hydrate |
| Synonym | Cycloblastin;Cyclostin;Cytoxan;Endoxan |
| MeltingPoint | 41-45°C |
| Solubility | Solubleinwater.Slightlysolubleinethanol. |
| Appearance | Whitecrystallinepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | C9609MSDSPDF |
|---|---|
| InfoSheet | C9609InfoSheetPDF |
SistiguA,ViaudS,ChaputN,etal.Immunomodulatoryeffectsofcyclophosphamideandimplementationsforvaccinedesign.SeminImmunopathol.2011Jul;33(4):369-83.PMID:21611872.
MakhaniN,GormanMP,BransonHM,etal.Cyclophosphamidetherapyinpediatricmultiplesclerosis.Neurology.2009Jun16;72(24):2076-82.PMID:19439723.
HallAG,TilbyMJ.Mechanismsofactionof,andmodesofresistanceto,alkylatingagentsusedinthetreatmentofhaematologicalmalignancies.BloodRev.1992Sep;6(3):163-73.PMID:1422285.
