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商品详细LKT/CYCLOPHOSPHAMIDE MONOHYDRATE/C9609/5 g
LKT/CYCLOPHOSPHAMIDE MONOHYDRATE/C9609/5 g
LKT/CYCLOPHOSPHAMIDE MONOHYDRATE/C9609/5 g
商品编号: C9609-5g
品牌: lktlabs
市场价: ¥3740.00
美元价: 2244.00
产地: 美国(厂家直采)
公司:
产品分类: 临床研究
公司分类: clinical_research
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

Cyclophosphamide is a nitrogen mustard that acts as an alkylator, adding alkyl groups to the N7 nitrogen of guanine bases; this inhibits DNA repair and replication. Cyclophosphamide exhibits anticancer chemotherapeutic and immunomodulatory activities. This compound is one component in the CHOP chemotherapy regimen. Cyclophosphamide is clinically used to treat various cancers, graft-versus-host disease (GvHD), and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematous (SLE).

Product Info

Cas No.

6055-19-2

Purity

≥98%

Formula

C7H15Cl2N2O2P • H2O

Formula Wt.

279.10

Chemical Name

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-ox- azaphosphorin-2-amine 2 oxide monohydrate

IUPAC Name

N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine;hydrate

Synonym

Cycloblastin; Cyclostin; Cytoxan; Endoxan

Melting Point

41-45°C

Solubility

Soluble in water. Slightly soluble in ethanol.

Appearance

White crystalline powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C9609 MSDS PDF

Info Sheet

C9609 Info Sheet PDF

References

Sistigu A, Viaud S, Chaput N, et al. Immunomodulatory effects of cyclophosphamide and implementations for vaccine design. Semin Immunopathol. 2011 Jul;33(4):369-83. PMID: 21611872.

Makhani N, Gorman MP, Branson HM, et al. Cyclophosphamide therapy in pediatric multiple sclerosis. Neurology. 2009 Jun 16;72(24):2076-82. PMID: 19439723.

Hall AG, Tilby MJ. Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies. Blood Rev. 1992 Sep;6(3):163-73. PMID: 1422285.

品牌介绍
LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。 试剂