Description
DeoxynivalenolisatrichothecenemycotoxininitiallyproducedbyspeciesofFusariumthatisfoundincerealsandotherproductsofwheatorsimilargrains.Deoxynivalenolexhibitsimmunomodulatory,cytotoxic,andpro-inflammatoryactivities.Invivo,deoxynivalenolincreasestheformationofporesintheintestinalepithelialbarrierofthejejunum,increasesthenumberofCD16+cells,anddownregulatesexpressionofsyndeca,fibulin6,andBM-40.Invitro,thistoxinactivatesp38MAPKandp53toinduceactivationofcaspases3,8,and9,resultinginapoptosis;italsoinducesrRNAcleavage,inhibitingribosomaltranslation.Inothercellularmodels,deoxynivalenolupregulatesexpressionofIL-1β,IL-6,TNF-α,COX-2,andmPGES-1.
References
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