DesloratADIneisanon-sedatingtricyclicantihistaminethatinhibitsH1histaminereceptors.Desloratidineisanactivemetaboliteofloratadinethatexhibitsanti-allergic,anti-asthma,andanti-inflammatoryactivities.Desloratadineinhibitshistamine-inducedbronchoconstrictionandisclinicallyusedtotreatallergicrhinitisandchronicidiopathicurticaria.Thiscompoundalsoactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).
| CasNo. | 100643-71-8 |
|---|---|
| Purity | ≥97% |
| Formula | C19H19ClN2 |
| FormulaWt. | 310.82 |
| ChemicalName | 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2,b]pyridine |
| IUPACName | 8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine |
| Synonym | Clarinex |
| MeltingPoint | 150-151°C |
| Solubility | Solubleinmethanolandethanol. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | D1774MSDSPDF |
|---|---|
| InfoSheet | D1774InfoSheetPDF |
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GlassDJ,HarperAS.Assessingsatisfactionwithdesloratadineandfexofenadineinallergypatientswhoreportdissatisfactionwithloratadine.BMCFamPract.2003Aug13;4:10.PMID:12917016.
WalshGM.Second-generationantihistaminesinasthmatherapy:isthereaprotectiveeffect?AmJRespirMed.2002;1(1):27-34.PMID:14720073.
