Dexamethasoneisaglucocorticoidthatexhibitsanti-inflammatoryandimmunosuppressiveactivitieswithminimalmineralocorticoideffect.Underinflammatoryconditions,dexamethasonedecreasessecretionofTNF,IL-6,andIL-1β,inhibitingmigrationandmaturationofmacrophages.Dexamethasonemayalsodisplayanti-asthmabenefitaswell,throughtheupregulationofPTENexpression.Additionally,dexamethasoneisoftenusedincombinationwithotherchemotherapeuticsinthetreatmentofmultiplemyeloma.
| CasNo. | 55812-90-3 |
|---|---|
| Purity | ≥98% |
| Formula | C24H31FO6•H2O |
| FormulaWt. | 452.52 |
| ChemicalName | (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-acetate |
| IUPACName | [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl]acetate;hydrate |
| Synonym | Dexamethasone21-Acetate;Decadronal;Dectancyl;Dexacortisyl |
| MeltingPoint | 229-231°C |
| Appearance | Whitecrystallinepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | D1694MSDSPDF |
|---|---|
| InfoSheet | D1694InfoSheetPDF |
BartneckM,PetersFM,WarzechaKT,etal.Liposomalencapsulationofdexamethasonemodulatescytotoxicity,inflammatorycytokineresponse,andmigratorypropertiesofprimaryhumanmacrophages.Nanomedicine.2014Mar7.[Epubaheadofprint].PMID:24607939.
NiZ,TangJ,CaiZ,etal.AnewpathwayofglucocorticoidactionforasthmatreatmentthroughtheregulationofPTENexpression.RespirRes.2011Apr14;12:47.PMID:21489309.
MorganG.Futuredrugdevelopmentsinmultiplemyeloma:anoverviewofnovellenalidomide-basedcombinationtherapies.BloodRev.2010Nov;24Suppl1:S27-32.PMID:21126634.
