Description
Dimethylfumarateisafumaricacidmethylesterthatisclinicallyusedtotreatpsoriasisandunderinvestigationasapotentialtreatmentformultiplesclerosis(MS).Dimethylfumarateexhibitsimmunomodulatory,antioxidative,andanti-inflammatoryactivities.Invitro,dimethylfumarateincreasesexpressionofhemeoxygenase1(HO-1)andNrf2anddecreasesproliferationofTcellsandreleaseofinflammatorycytokines.Dimethylfumarateactivatesnicotinicacetylcholinereceptors(nAChRs),althoughtherelevanceofthisactivityisunknown.Previously,thiscompoundhasbeenusedasarADIosensitizer.Recently,dimethylfumaratehasdisplayedefficacyinmodelsofmultiplesclerosis,decreasingrelapseandimprovingneurologicoutcomes.
References
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