Description
DiosmetinisanO-methylatedflavonefoundinvetchandvariouscitrusfruits;itexhibitsantioxidative,anti-inflammatory,anticancer,andanti-osteoporoticactivities.InanimalmodelsofAAPH-inducedoxidativestress,diosmetindecreasesgenerationofROSandincreaseslevelsofsuperoxidedismutase,catalase,andglutathioneperoxidase.Diosmetinalsodecreasesamylase,lipase,TNF-α,IL-1β,IL-6,andiNOSinanimalmodelsofpancreatitis.Inbreastcancercells,diosmetininducesG1phasecellcyclearrestandinhibitscellularproliferation.Additionally,thiscompoundincreasesactivationofPKC,ERK1/2,andp38MAPK,inducingosteoblasticdifferentiationinvitro.
References
LiaoW,NingZ,ChenL,etal.IntracellularAntioxidantDetoxifyingEffectsofDiosmetinon2,2-Azobis(2-amidinopropane)Dihydrochloride(AAPH)-InducedOxidativeStressthroughInhibitionofReactiveOxygenSpeciesGeneration.JAgricFoodChem.2014Aug27;62(34):8648-54.PMID:25075433.
YuG,WanR,YinG,etal.Diosmetinamelioratestheseverityofcerulein-inducedacutepancreatitisinmicebyinhibitingtheactivationofthenuclearfactor-κB.IntJClinExpPathol.2014Apr15;7(5):2133-42.PMID:24966921.
AndroutsopoulosVP,MahaleS,ArrooRR,etal.AnticancereffectsoftheflavonoiddiosmetinoncellcycleprogressionandproliferationofMDA-MB468breastcancercellsduetoCYP1activation.OncolRep.2009Jun;21(6):1525-8.PMID:19424633.
HsuYL,KuoPL.DiosmetininduceshumanosteoblasticdifferentiationthroughtheproteinkinaseC/p38andextracellularsignal-regulatedkinase1/2pathway.JBoneMinerRes.2008Jun;23(6):949-60.PMID:18269307.
