Description
Quinestrolisasyntheticestrogenhomologthatexhibitsanti-fertilityandcontraceptiveactivities.QuinestrolisanERagoNISTandisalsousedinHRT.Quinestrolisdisplaysclinicalbenefitinimprovingsymptomsofpostmenopausalsyndrome.Inmales,quinestroldecreasestheweightofthetestis,epididymis,seminalvesicle,andprostate,decreasesspermcount,anddecreaseslevelsoftestosterone,lutropin,andfollitropin.Infemales,quinestroldecreaseslevelsoffollicle-stimulatinghormone(FSH)andluteinizinghormone(LH),increaseslevelsofprogesteroneandestrADIol,andaltersestrogenreceptorexpression.Quinestrolincreasesoxidativestressbydecreasingactivityofsuperoxidedismutase(SOD)andglutathioneperoxidaseandincreasinglevelsofNOandmalondialdehyde.Inotheranimalmodels,thiscompoundinhibitsinvestigativereproductivebehavior.