Pranoprofenisanon-steroidalanti-inflammatorydrug(NSAID)thatexhibitsanti-inflammatoryactivity;itisclinicallyusedtotreatdryeye.PranoprofeninhibitsCOX-1andCOX-2.Pranoprofeninhibitsproductionofsodiumurate-inducedsuperoxide,prostaglandinE2(PGE2),andβ-glucuronidase.
| CasNo. | 52549-17-4 |
|---|---|
| Purity | ≥98% |
| Formula | C15H13NO3 |
| FormulaWt. | 255.27 |
| ChemicalName | α-Methyl-5H-[1]benzopyranol[2,3-b]pyridine-7-aceticacid |
| IUPACName | 2-(5H-chromeno[2,3-b]pyridin-7-yl)propanoicacid |
| Synonym | Y-8004;Niflan |
| MeltingPoint | 182-183°C |
| Appearance | WhiteorLightyellowcrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P6802InfoSheetPDF |
|---|
ChenJ,DongF,ChenW,etal.Clinicalefficacyof0.1%pranoprofenintreatmentofdryeyepatients:amulticenter,randomized,controlledclinicaltrial.ChinMedJ(Engl).2014Jul;127(13):2407-12.PMID:24985574.
ArataniH,IwahisaY,ImayoshiT,etal.Mechanismoftheinhibitoryeffectofpranoprofenonsodiumuratecrystal-inducedinflammation.NihonYakurigakuZasshi.1987Mar;89(3):139-44.PMID:3556352.
