Prednisoloneisaderivativeofcortisolandametaboliteofprednisone;itexhibitsimmunosuppressiveandanti-inflammatoryactivities.Prednisoloneactivatesglucocorticoidreceptorsandisclinicallyusedtotreatinflammatoryandautoimmunedisorders.Inmononuclearcellsfromsubjectswithmultiplesclerosis,prednisolonedecreasesexpressionofT-bet,IFNγ,andphosphorylatedSTAT1,decreasinglymphocyteapoptosis.Additionally,prednisolonedelaystheprogressionofDuchennemusculardystrophy(DMD),alteringmusclefibertypesinvivo.
| CasNo. | 50-24-8 |
|---|---|
| Purity | ≥98% |
| Formula | C21H28O5 |
| FormulaWt. | 360.44 |
| ChemicalName | (11β)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione |
| IUPACName | (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
| Synonym | Cortalone;Decaprednil;DecortinH;Deltasolone;Flamasone;Hydrodeltalone;Paracortol;Sterolone |
| MeltingPoint | 240-241°C(dec) |
| Solubility | Slightlysolubleinwater(1mM).Solubleinmethanolanddioxane.Solubleinethanol(33mg/mL),DMSO(633mM) |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P6818InfoSheetPDF |
|---|
FrisulloG,NocitiV,IorioR,etal.GlucocorticoidtreatmentreducesT-betandpSTAT1expressioninmononuclearcellsfromrelapsingremittingmultiplesclerosispatients.ClinImmunol.2007Sep;124(3):284-93.PMID:17627892.
FisherI,AbrahamD,BouriK,etal.Prednisolone-inducedchangesindystrophicskeletalmuscle.FASEBJ.2005May;19(7):834-6.Erratumin:FASEBJ.2005May;19(7):1pfollowing836.Hoffmann,EricP[correctedtoHoffman,EricP].PMID:15734791.
DavisM,WilliamsR,ChakrabortyJ,etal.Prednisoneorprednisoloneforthetreatmentofchronicactivehepatitis?AcomparisonofplasmaavailABIlity.BrJClinPharmacol.1978Jun;5(6):501-5.PMID:656293.
