Description
Procaterol is an agonist at β2-adrenergic receptors that exhibits anti-inflammatory, anti-asthma, and bronchodilatory activities. Procaterol is used to treat asthma. In animal models, procaterol suppresses anaphylactic reactions. In bronchial epithelial cells, procaterol inhibits release of RANTES, GM-CSF, and IL-8, inhibiting eosinophil chemotaxis. Additionally, procaterol decreases expression of intracellular adhesion molecule 1 (ICAM-1) and vascular cellular adhesion molecule 1 (VCAM-1), inhibiting adhesion of eosinophils to fibroblasts.
References
Bao W, Chen Q, Lin Y, et al. Efficacy of procaterol combined with inhaled budesonide for treatment of cough-variant asthma. Respirology. 2013 Nov;18 Suppl 3:53-61. PMID: 24188204.
Yoshida N, Muraguchi M, Kamata M, et al. Procaterol potentiates the anti-inflammatory activity of budesonide on eosinophil adhesion to lung fibroblasts. Int Arch Allergy Immunol. 2009;150(4):352-8. PMID: 19571567.
Koyama S, Sato E, Masubuchi T, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75. PMID: 10573218.
Ohuchi K, Hirasawa N, Takeda H, et al. Mechanism of antianaphylactic action of beta-agonists in allergic inflammation of air pouch type in rats. Int Arch Allergy Appl Immunol. 1987;82(1):26-32. PMID: 2879797.
