Flumequineisafluoroquinoloneantibioticcommonlyusedinveterinarymedicine.FlumequineexhibitsantibacterialefficacythroughtheinhibitionofbacterialDNAgyrase.Thiscompoundalsodisplaysotheractivity,inhibitingGABA-Areceptorsintheileum,anddisplayscancer-relatedactivityintheliver,althoughreportsconflictastowhetherflumequineischemopreventiveorcarcinogenic.Additionally,thiscompoundwaspreviouslyexploredasatreatmentforurinarytractinfectioninhumans,althoughisnotcurrentlyusedinthatmanner.
| Purity | ≥98% |
|---|---|
| Formula | C14H11FNNaO3 |
| FormulaWt. | 283.23 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | F4881InfoSheetPDF |
|---|
KuroiwaY,UmemuraT,NishikawaA,etal.LackofinvivomutagenicityandoxidativeDNAdamagebyflumequineintheliversofgptdeltamice.ArchToxicol.2007Jan;81(1):63-9.PMID:16802149.
Vik-MoFT,BerghO,SamuelsenOB.EfficacyoforallyadmiNISTeredflumequineinthetreatmentofvibriosiscausedbyListonellaanguillaruminatlanticcodGadusmorhua.DisAquatOrgan.2005Nov9;67(1-2):87-92.PMID:16385813.
Koutsoviti-PapadopoulouM,KounenisG,ElezoglouV.Inhibitoryeffectofflumequine,enoxacinandnorfloxacinontheGABA-inducedcontractileeffectontheguineapigileum.GenPharmacol.1995Oct;26(6):1391-5.PMID:7590136.
SchenaFP,GesualdoL,CaraccioloG.Amulticentrestudyofflumequineinthetreatmentofurinarytractinfections.JAntimicrobChemother.1988Jan;21(1):101-6.PMID:3356617.
SmithJT.Themodeofactionof4-quinolonesandpossIBLemechanismsofresistance.JAntimicrobChemother.1986Nov;18SupplD:21-9.PMID:3542946.
