Flutriafolisatriazoleantifungalpesticide;itactsasademethylationinhibitor,preventingsterolbiosynthesisanddisruptingmembranefunction.Flutriafolmayalsoexhibitneuromodulatoryandantioxidativeactivityinvivo,asitinducesreleaseofdopamineintheratstriatumthroughoverstimulationofNMDAreceptorsandincreasingNOproduction.Flutriafol-evokeddopaminereleasealsoappearstobedependentonNa+andCa2+signaling.
| CasNo. | 76674-21-0 |
|---|---|
| Purity | ≥95% |
| Formula | C16H13F2N3O |
| FormulaWt. | 301.29 |
| IUPACName | 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)ethanol |
| Appearance | Whitetoyellowishpowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | F4883InfoSheetPDF |
|---|
FaroLR,AlfonsoM,MauésLA,etal.Roleofionotropicglutamatergicreceptorsandnitricoxideintheeffectsofflutriafol,atriazolefungicide,ontheinvivostriataldopaminerelease.JToxicolSci.2012;37(6):1135-42.PMID:23208429.
SantanaMB,RodriguesKJ,DuránR,etal.Evaluationoftheeffectsandmechanismsofactionofflutriafol,atriazolefungicide,onstriataldopaminereleasebyusinginvivomicrodialysisinfreelymovingrats.EcotoxicolEnvironSaf.2009Jul;72(5):1565-71.PMID:19232726.
GriffithsKM,HowlettBJ.TranscriptionofsterolDelta(5,6)-desaturaseandsterol14alpha-demethylaseisinducedintheplantpathogenicascomycete,Leptosphaeriamaculans,duringtreatmentwithatriazolefungicide.FEMSMicrobiolLett.2002Nov19;217(1):81-7.PMID:12445649.
