Forchlorfenuronisasyntheticcytokininthatinhibitsseptinsandexhibitsanti-parasitic,anticancer,andanti-angiogenicactivities.Forchlorfenuroninducespolymerizationoffilaments,causingparalysisinSchistosoma.ThiscompoundalsoinhibitsproliferationandmigrationofprostatecancercellsbyinducingdegradationofHIF-1αinaproteasome-dependentmanner.Forchlorfenuroniscommonlyusedasaplantgrowthregulator.
| CasNo. | 68157-60-8 |
|---|---|
| Purity | ≥98% |
| Formula | C12H10ClN3O |
| FormulaWt. | 247.68 |
| ChemicalName | N-(2-chloro-4-pyridinyl)-N"-phenyl-Urea |
| IUPACName | 1-(2-chloropyridin-4-yl)-3-phenylurea |
| Synonym | KT-30 |
| MeltingPoint | 165-170°C |
| Solubility | Solubleinwater(39mg/L)atpH6.4. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | F5766InfoSheetPDF |
|---|
ZeraikAE,GalkinVE,RinaldiG,etal.ReversIBLeparalysisofSchistosomamansonibyforchlorfenuron,aphenylureacytokininthataffectsseptins.IntJParasitol.2014Apr21.[Epubaheadofprint].PMID:24768753.
Vardi-OkninD,GolanM,MabjeeshNJ.ForchlorfenurondisruptsSEPT9_i1filamentsandinhibitsHIF-1.PLoSOne.2013Aug19;8(8):e73179.PMID:23977378.
HuQ,NelsonWJ,SpiliotisET.Forchlorfenuronaltersmammalianseptinassembly,organization,anddynamics.JBiolChem.2008Oct24;283(43):29563-71.PMID:18713753.
