LKT/FUMAGILLIN/F8048/1 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/FUMAGILLIN/F8048/1 mg

LKT/FUMAGILLIN/F8048/1 mg

商品编号： F8048-1mg

品牌： lktlabs

市场价： ¥1240.00

美元价： 744.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDF8048

CasNo.23110-15-8

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

FumagillinisanantimicrobialcompoundinitiallyproducedbyspeciesofAspergillusthatexhibitsanti-parasitic,antimalarial,anti-fibrotic,anti-angiogenic,andanticancerchemotherapeuticactivities.FumagillinisclinicallyusedtotreatmicrosporidiosisanddisplaysefficacyagainstPlasmodium,Nosema,andEnterocytozoon.Invivo,fumagillindecreasespulmonaryfibrosis,pulmonaryhypertension,andventricularremodeling.Incellularandanimalmodelsofcolorectalcancer,fumagillininhibitstype2methionineaminopeptidase,preventingtubeandvesselformationandwellascellproliferation,migration,andadhesion;italsodecreasestumormass.

ProductInfo

CasNo.	23110-15-8
Purity	≥98%
Formula	C₂₆H₃₄O₇
FormulaWt.	458.54
ChemicalName	[3R-[3α,4α(2R,3R),5β,6β(all-E)]]-2,4,6,8-Decatetra-enedioicacid,mono[5-methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl]ester
IUPACName	(2Z,4E,6E,8E)-10-[[5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoicacid
Synonym	Amebacilin;Fugillin;FumADIlB:Fumidil
MeltingPoint	194-195°C
Solubility	Solubleinmostorganicsolvents.Practicallyinsolubleinwater,diluteacidsandsaturatedhydrocarbons.
Appearance	OffwhitePowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	F8048MSDSPDF
InfoSheet	F8048InfoSheetPDF

References

KassDJ,RattiganE,KahloonR,etal.Earlytreatmentwithfumagillin,aninhibitorofmethionineaminopeptidase-2,preventsPulmonaryHypertensioninmonocrotaline-injuredrats.PLoSOne.2012;7(4):e35388.PMID:22509410.

ChampionL,DurrbachA,LangP,etal.Fumagillinfortreatmentofintestinalmicrosporidiosisinrenaltransplantrecipients.AmJTransplant.2010Aug;10(8):1925-30.PMID:20636462.

Arico-MuendelC,CentrellaPA,ContonioBD,etal.Antiparasiticactivitiesofnovel,orallyavailablefumagillinanalogs.BioorgMedChemLett.2009Sep1;19(17):5128-31.PMID:19648008.

HouL,MoriD,TakaseY,etal.Fumagillininhibitscolorectalcancergrowthandmetastasisinmice:invivoandinvitrostudyofanti-angiogenesis.PatholInt.2009Jul;59(7):448-61.PMID:19563408.

ChenX,XieS,BhatS,etal.FumagillinandfumarranolinteractwithP.falciparummethionineaminopeptidase2andinhibitmalariaparasitegrowthinvitroandinvivo.ChemBiol.2009Feb27;16(2):193-202.PMID:19246010.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂