Geldanamycinisaninhibitorofheatshockprotein90(HSP90)thatexhibitsantiviral,neuroprotective,andanticanceractivities.GeldanamycindecreasesviraltitersandinflammationinanimalmodelsofChikungunyavirusinfection.Geldanamycinalsoacceleratesnerveregenerationandenhancesfunctionalrecoveryinanimalmodelsofnervecrushinjury.Additionally,geldanamycinsensitizesvariouscancercelllinestotheeffectsofotherco-admiNISTeredchemotherapeutics.
| CasNo. | 30562-34-6 |
|---|---|
| Purity | ≥97% |
| Formula | C29H40N2O9 |
| FormulaWt. | 560.64 |
| IUPACName | [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azABIcyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl]carbamate |
| Synonym | BRN1633093 |
| MeltingPoint | 265-268°C |
| Solubility | SolubleinDMSO. |
| Appearance | YellowPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | G1646MSDSPDF |
|---|---|
| InfoSheet | G1646InfoSheetPDF |
RathoreAP,HaysteadT,DasPK,etal.ChikungunyavirusnsP3&nsP4interactswithHSP-90topromotevirusreplication:HSP-90inhibitorsreduceCHIKVinfectionandinflammationinvivo.AntiviralRes.2014Mar;103:7-16.PMID:24388965.
SunHH,Saheb-Al-ZamaniM,YanY,etal.GeldanamycinacceleratedperipheralnerveregenerationincomparisontoFK-506invivo.Neuroscience.2012Oct25;223:114-23.PMID:22835622.
McNamaraAV,BarclayM,WatsonAJ,etal.Hsp90inhibitorssensitisehumancoloncancercellstotopoisomeraseIpoisonsbydepletionofkeyanti-apoptoticandcellcyclecheckpointproteins.BiochemPharmacol.2012Feb1;83(3):355-67.PMID:22138446.
