LKT/甘草酸水合铵/G4598/10g-免疫在线蚂蚁淘旗下平台

商品详细LKT/甘草酸水合铵/G4598/10g

LKT/甘草酸水合铵/G4598/10g

商品编号： G4598-10g

品牌： lktlabs

市场价： ¥900.00

美元价： 540.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDG4598

CasNo.53956-04-0

Purity≥93%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

GlycyrrhizinisatriterpeneglycosidefoundinGlycyrrhizathatexhibitsantiviral,anti-inflammatory,nephroprotective,neuroprotective,anticancer,chemopreventive,andantioxidativeactivities.Glycyrrhiziniscommerciallyusedasaflavorantandemulsifier.Thiscompoundinhibits11β-hydroxysteroiddehydrogenase.Glycyrrhizinisoccasionallyclinicallyusedtotreatherpesvirusinfections,asitinhibitsviralentrytohostcells.Glycyrrhizinalsoinhibitsrenalischemia/reperfusioninjuryinvivobydownregulatingsignalingofp38MAPKanddecreasingexpressionofIL-6,IL-1β,IFN-γ,andTNF-α.Invitro,glycyrrhizindecreaseslevelsofROSandmalondialdehydeandincreaseslevelsofsuperoxidedismutase.Inotherinvitromodels,glycyrrhizinpreventsglialinflammationandkainicacid-inducedneuronaldeath.ThiscompoundpreventsthedevelopmentofDMH-inducedcancerouslesionsinthecolon,inducesapoptosisandexpressionofp53,anddecreaseslevelsofinflammatorycytokines,COX-2,andVEGF;italsoinhibitscellularproliferationandgrowthinprostatecancercells.

ProductInfo

CasNo.	53956-04-0
Purity	≥93%
Formula	C₄₂H₆₂NO₁₆•xH₂O
FormulaWt.	839.97
ChemicalName	(3β,20β)-20-Carboxy-11-oxo-30-norolean-2-en-3-yl2-O-β-D-glucopyranuronosyl-a-D-glucopyranosIduronicacid
IUPACName	(2S,3S,4S,5R,6R)-6-[(3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylicacid;azane
Synonym	Glycyrrhizin;glycyrrhizinicacid;glycyrrhetinicacidglycoside
MeltingPoint	209-211°C
Solubility	Solubleinhotwaterorethanol.
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	G4598MSDSPDF
InfoSheet	G4598InfoSheetPDF

References

YeS,ZhuY,MingY,etal.Glycyrrhizinprotectsmiceagainstrenalischemia-reperfusioninjurythroughinhibitionofapoptosisandinflammationbydownregulatingp38mitogen-activatedproteinkinasesignaling.ExpTherMed.2014May;7(5):1247-1252.PMID:24940420.

SonM,LeeM,SungGH,etal.Bioactiveactivitiesofnaturalproductsagainstherpesvirusinfection.JMicrobiol.2013Oct;51(5):545-51.Erratumin:JMicrobiol.2013Dec;51(6):888.PMID:24173639.

LuoL,JinY,KimID,etal.GlycyrrhizinattenuateskainicAcid-inducedneuronalcelldeathinthemousehippocampus.ExpNeurobiol.2013Jun;22(2):107-15.PMID:23833559.

FengL,ZhuMM,ZhangMH,etal.ProtectionofglycyrrhizicacidagainstAGEs-inducedendothelialdysfunctionthroughinhibitingRAGE/NF-κBpathwayactivationinhumanumbilicalveinendothelialcells.JEthnopharmacol.2013Jun21;148(1):27-36.PMID:23528363.

KhanR,KhanAQ,LateefA,etal.Glycyrrhizicacidsuppressesthedevelopmentofprecancerouslesionsviaregulatingthehyperproliferation,inflammation,angiogenesisandapoptosisinthecolonofWistarrats.PLoSOne.2013;8(2):e56020.PMID:23457494.

ShettyAV,ThirugnanamS,DakshinamoorthyG,etal.18α-glycyrrhetinicacidtargetsprostatecancercellsbydown-regulatinginflammation-relatedgenes.IntJOncol.2011Sep;39(3):635-40.PMID:21637916.

MichaelisM,GeilerJ,NaczkP,etal.GlycyrrhizinexertsantioxidativeeffectsinH5N1influenzaAvirus-infectedcellsandinhibitsvirusreplicationandpro-inflammatorygeneexpression.PLoSOne.2011;6(5):e19705.PMID:21611183.

WolkerstorferA,KurzH,BachhofnerN,etal.GlycyrrhizininhibitsinfluenzaAvirusuptakeintothecell.AntiviralRes.2009Aug;83(2):171-8.PMID:19416738.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂