LKT/GOSSYPOL/G5874/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/GOSSYPOL/G5874/25 mg

LKT/GOSSYPOL/G5874/25 mg

商品编号： G5874-25mg

品牌： lktlabs

市场价： ¥1040.00

美元价： 624.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDG5874

CasNo.303-45-7

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

GossypolisapolyphenolfoundinGossypiumthatexhibitsanti-fertility,antimalarial,immunosuppressive,antiviral,andanticancerchemotherapeuticactivities.Gossypolinhibitscalcineurin,PKC,andotherkinases.Gossypolisunderconsiderationforuseasamalecontraceptiveasitinducesspermatogenesisarrest.GossypolalsoinactivatesHIV-1invitroandinhibitsviralentryofH5N1influenzavirus.Invitro,gossypolinhibitsConA-inducedincreasesinNF-κB,NFAT,andAP-1signaling,suppressingTcellactivationinvitro.GossypolalsoactsasaBH3mimetic,inhibitingBcl-2andBcl-xl,inducingG2/MphasecellcyclearrestinwildtypeandB-RAFmutantmelanomaandmyelomacells.

ProductInfo

CasNo.	303-45-7
Purity	≥98%
Formula	C₃₀H₃₀O₈
FormulaWt.	518.55
ChemicalName	1,1",6,6",7,7"-Hexahydroxy-3,3"-dimethyl-5,5"-bis(1-methylethyl)[2,2"-binaphthalene]-8,8"-dicarboxaldehyde
IUPACName	7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde
Synonym	2,2"-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)
MeltingPoint	198
Solubility	SolubleinDMSO,methanolorethanol.Insolubleinwater.
Appearance	BrightYellowPowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	G5874MSDSPDF
InfoSheet	G5874InfoSheetPDF

References

JangGH,LeeM.BH3-mimeticgossypol-inducedautophagiccelldeathinmutantBRAFmelanomacellswithhighexpressionofp21Cip¹.).LifeSci.2014Apr25;102(1):41-8.PMID:24625733.

SongB,HuangG,TongC,etal.GossypolsuppressesmouseTlymphocytesviainhibitionofNFκB,NFATandAP-1pathways.ImmunopharmacolImmunotoxicol.2013Oct;35(5):615-21.PMID:23981004.

LinJ,WuY,YangD,etal.InductionofapoptosisandantitumoreffectsofasmallmoleculeinhibitorofBcl-2andBcl-xl,gossypolacetate,inmultiplemyelomainvitroandinvivo.OncolRep.2013Aug;30(2):731-8.PMID:23708869.

YangJ,ChenG,LiLL,etal.Synthesisandanti-H5N1activityofchiralgossypolderivativesanditsanalogsimplicatedbyaviralentryblockingmechanism.BioorgMedChemLett.2013May1;23(9):2619-23.PMID:23538114.

CoutinhoEM.Gossypol:acontraceptiveformen.Contraception.2002Apr;65(4):259-63.PMID:12020773.

PolskyB,SegalSJ,BaronPA,etal.Inactivationofhumanimmunodeficiencyvirusinvitrobygossypol.Contraception.1989Jun;39(6):579-87.PMID:2473865.

VolateSR,KawasakiBT,HurtEM,etal.Gossypolinducesapoptosisbyactivatingp53inprostatecancercellsandprostatetumor-initiatingcells.MolCancerTher.2010Feb;9(2):461-470.PMID:20124455.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂