LKT/GOSSYPOL ACETIC ACID/G5875/1 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/GOSSYPOL ACETIC ACID/G5875/1 g

LKT/GOSSYPOL ACETIC ACID/G5875/1 g

商品编号： G5875-1g

品牌： lktlabs

市场价： ¥8860.00

美元价： 5316.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product ID G5875

Cas No. 12542-36-8

Purity ≥98%

Description
Product Info
Shipping and Storage
Downloads
References

Description

Gossypol acetic acid (GA) exhibits anticancer chemotherapeutic, pro-oxidative, antioxidative, and antibacterial activities. GA inhibits Bcl-2/Bcl-xl, enhancing TRAIL/mitochondria-induced apoptosis in breast cancer cells. In animal models, GA delayed the onset of androgen-independent prostate cancer. In macrophages, GA increases production of ROS, upregulates expression of caspases 3 and 9, and decreases the mitochondrial membrane potential, inducing apoptosis. GA increases activity of glutathione peroxidase and inhibits lipid peroxidation but also increases generation of ROS and induces DNA damage. This compound also exhibits antibiotic activity, inhibiting growth of gram negative bacteria such as Edwardsiella. Additionally, GA has been studied as a male contraceptive; it inhibits sialyl transferase activity in seminal plasma, decreases tubulin content and spermatocyte mobility, and reversibly inhibits spermatogenesis in vivo.

Product Info

Cas No.	12542-36-8
Purity	≥98%
Formula	C₃₀H₃₀O₈ • C₂H₄O₂
Formula Wt.	578.61
Chemical Name	1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1- methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehyde-acetic acid
IUPAC Name	acetic acid;7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde
Synonym	2,2'-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)-acetic acid
Melting Point	184
Solubility	Soluble in DMSO, methanol or ethanol. Insoluble in water.
Appearance	Yellow Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	G5875 MSDS PDF
Info Sheet	G5875 Info Sheet PDF

References

Deng S, Yuan H, Yi J, et al. Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway. J Vet Sci. 2013;14(3):281-9. PMID: 23820203.

Hall C, Troutman SM, Price DK, et al. Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms. Clin Genitourin Cancer. 2013 Mar;11(1):10-9. PMID: 23083798.

Kisim A, Atmaca H, Cakar B, et al. Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. J Cancer Res Clin Oncol. 2012 Jul;138(7):1155-63. PMID: 22411600.

El-Sharaky AS, Wahby MM, Bader El-Dein MM, et al. Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats. Food Chem Toxicol. 2009 Nov;47(11):2735-41. PMID: 19665044.

Loberg RD, McGregor N, Ying C, et al. In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Neoplasia. 2007 Dec;9(12):1030-7. PMID: 18084610.

Yildirim-Aksoy M, Lim C, Dowd MK, et al. In vitro inhibitory effect of gossypol from gossypol-acetic acid, and (+)- and (-)-isomers of gossypol on the growth of Edwardsiella ictaluri. J Appl Microbiol. 2004;97(1):87-92. PMID: 15186445.

Sharma S, Kumar M, Goyal RB, et al. Reversible antispermatogenic effect of gossypol in langur monkeys (Presbytis entellus entellus). Adv Contracept. 1999;15(1):15-27. PMID: 10794043.

Teng CS. Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. Contraception. 1997 Jan;55(1):41-6. PMID: 9013060.

Levinsky H, Singer R, Sagiv M, et al. Inhibition of sialyl transferase activity by gossypol acetic acid in human seminal plasma. Andrologia. 1991 Mar-Apr;23(2):159-61. PMID: 1952122.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂