Herbimycin A is a benzoquinone ansamycin antibiotic that also exhibits anticancer activity. Herbimycin A inhibits HSP90, PKC, and some Src family kinases such as Src and Bcr-Abl. Herbimycin A inhibits cell proliferation in various in vitro cancer models, including chronic myelogenous leukemia (CML).
| Cas No. | 70563-58-5 |
|---|---|
| Purity | ≥98% |
| Formula | C30H42N2O9 |
| Formula Wt. | 574.66 |
| IUPAC Name | [(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate |
| Synonym | Herbimycin |
| Solubility | Soluble in DMSO. |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | H1669 MSDS PDF |
|---|---|
| Info Sheet | H1669 Info Sheet PDF |
Kasai S, Kikuchi H. The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin a, genistein, and tyrphostin B48 with regard to the function of the aryl hydrocarbon receptor in Caco-2 cells. Biosci Biotechnol Biochem. 2010;74(1):36-43. PMID: 20057149.
Napolitano M, Bravo E. Activation of protein kinase C by phorbol esters in human macrophages reduces the metabolism of modified LDL by down-regulation of scavenger receptor activity. Int J Biochem Cell Biol. 2003 Jul;35(7):1127-43. PMID: 12672483.
Mucha DR, Myers CL, Schaeffer RC Jr. Endothelial contraction and monolayer hyperpermeability are regulated by Src kinase. Am J Physiol Heart Circ Physiol. 2003 Mar;284(3):H994-H1002. PMID: 12456392.
Ren H, Chen S, Lu D. Herbimycin A enhances apoptotic effect of chemotherapeutic drugs on K562 cells. Chin Med J (Engl). 1998 Aug;111(8):678-81. PMID: 11245017.
Fukazawa H, Li PM, Yamamoto C, et al. Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro. Biochem Pharmacol. 1991 Oct 9;42(9):1661-71. PMID: 1656993.
