HerbimycinAisabenzoquinoneansamycinantibioticthatalsoexhibitsanticanceractivity.HerbimycinAinhibitsHSP90,PKC,andsomeSrcfamilykinasessuchasSrcandBcr-Abl.HerbimycinAinhibitscellproliferationinvariousinvitrocancermodels,includingchronicmyelogenousleukemia(CML).
| CasNo. | 70563-58-5 |
|---|---|
| Purity | ≥98% |
| Formula | C30H42N2O9 |
| FormulaWt. | 574.66 |
| IUPACName | [(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azABIcyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl]carbamate |
| Synonym | Herbimycin |
| Solubility | SolubleinDMSO. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | H1669MSDSPDF |
|---|---|
| InfoSheet | H1669InfoSheetPDF |
KasaiS,KikuchiH.Theinhibitorymechanismsofthetyrosinekinaseinhibitorsherbimycina,geNISTein,andtyrphostinB48withregardtothefunctionofthearylhydrocarbonreceptorinCaco-2cells.BiosciBiotechnolBiochem.2010;74(1):36-43.PMID:20057149.
NapolitanoM,BravoE.ActivationofproteinkinaseCbyphorbolestersinhumanmacrophagesreducesthemetabolismofmodifiedLDLbydown-regulationofscavengerreceptoractivity.IntJBiochemCellBiol.2003Jul;35(7):1127-43.PMID:12672483.
MuchaDR,MyersCL,SchaefferRCJr.EndothelialcontractionandmonolayerhyperpermeabilityareregulatedbySrckinase.AmJPhysiolHeartCircPhysiol.2003Mar;284(3):H994-H1002.PMID:12456392.
RenH,ChenS,LuD.HerbimycinAenhancesapoptoticeffectofchemotherapeuticdrugsonK562cells.ChinMedJ(Engl).1998Aug;111(8):678-81.PMID:11245017.
FukazawaH,LiPM,YamamotoC,etal.SpecificinhibitionofcytoplasmicproteintyrosinekinasesbyherbimycinAinvitro.BiochemPharmacol.1991Oct9;42(9):1661-71.PMID:1656993.
