HygromycinBisanantibioticthatalsodisplaysantiviralactivity.Hygromycinbindsthe30Sribosomalsubunit,inhibitingproteinandRNAsynthesisofbacteriaorviruses;itinducesmisreADIngsatmultiplestepsinproteintranslationandsuppressestranslocation.Inanimalmodels,hygromycinBallowstranslationtooccurbutpreventsformationofviralantigenbyLeishmaniaand,separately,preventsinfectionbymurinehepatitisvirus.
| CasNo. | 31282-04-9 |
|---|---|
| Purity | ≥95.0% |
| Formula | C20H37N3O13 |
| FormulaWt. | 527.52 |
| IUPACName | 4-[3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6"-(1-amino-2-hydroxyethyl)-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2"-oxane]-3",4",5",7-tetrol |
| Appearance | BuffPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | H9726MSDSPDF |
|---|---|
| InfoSheet | H9726InfoSheetPDF |
BrodersenDE,ClemonsWMJr,CarterAP,etal.Thestructuralbasisfortheactionoftheantibioticstetracycline,pactamycin,andhygromycinBonthe30Sribosomalsubunit.Cell.2000Dec22;103(7):1143-54.PMID:11163189.
RoYT,ScheffterSM,PattersonJL.HygromycinBresistancemediateseliminationofLeishmaniavirusfrompersistentlyinfectedparasites.JVirol.1997Dec;71(12):8991-8.PMID:9371555.
MacintyreG,WoodsDE,AndersonR.HygromycinBinhibitssynthesisofmurinecoronavirusRNA.AntimicrobAgentsChemother.1991Dec;35(12):2630-3.PMID:1667257.
