Idoxuridineisanantiviralclinicallyusedtotreatherpessimplexkeratitisandotherocularherpesinfections.IdoxuridineisanucleosideanalogofdeoxyuridinethatisincorporatedintoDNA,inhibitingchainelongation.IdoxuridinealsoshowsbenefitasarADIation/chemotherapysensitizeringliomacells.
| CasNo. | 54-42-2 |
|---|---|
| Purity | ≥98% |
| Formula | C9H11IN2O5 |
| FormulaWt. | 354.10 |
| ChemicalName | 2"-Deoxy-5-iodouridine |
| IUPACName | 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione |
| Synonym | IdU"IdUR;IUdR;IdUrd;Dendrid;(+)-5-Iodo-2"-deoxyuridine |
| MeltingPoint | 164-166°C |
| Solubility | Slightlysolubleinwater(2mg/ml)oracetone(1.6mg/ml). |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | I1257InfoSheetPDF |
|---|
WilhelmusKR.Antiviraltreatmentandothertherapeuticinterventionsforherpessimplexvirusepithelialkeratitis.CochraneDatabaseSystRev.2010Dec8;(12):CD002898.PMID:21154352.
SchultzCJ,GaffneyDK,LindstromMJ,etal.Iododeoxyuridineradiosensitizationofhumanglioblastomacellsexposedtoacuteandchronicgammairradiation:mechaNISTicimplicationsandclinicalrelevance.CancerJSciAm.1995Jul-Aug;1(2):151-61.Erratumin:CancerJSciAm.1996Jan-Feb;2(1):15.PMID:9166468.
