Idoxuridine is an antiviral clinically used to treat herpes simplex keratitis and other ocular herpes infections. Idoxuridine is a nucleoside analog of deoxyuridine that is incorporated into DNA, inhibiting chain elongation. Idoxuridine also shows benefit as a radiation/chemotherapy sensitizer in glioma cells.
| Cas No. | 54-42-2 |
|---|---|
| Purity | ≥98% |
| Formula | C9H11IN2O5 |
| Formula Wt. | 354.10 |
| Chemical Name | 2'-Deoxy-5-iodouridine |
| IUPAC Name | 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione |
| Synonym | IdU' IdUR; IUdR; IdUrd; Dendrid; (+)-5-Iodo-2'-deoxyuridine |
| Melting Point | 164-166°C |
| Solubility | Slightly soluble in water (2 mg/ml) or acetone (1.6 mg/ml). |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | I1257 Info Sheet PDF |
|---|
Wilhelmus KR. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD002898. PMID: 21154352.
Schultz CJ, Gaffney DK, Lindstrom MJ, et al. Iododeoxyuridine radiosensitization of human glioblastoma cells exposed to acute and chronic gamma irradiation: mechanistic implications and clinical relevance. Cancer J Sci Am. 1995 Jul-Aug;1(2):151-61. Erratum in: Cancer J Sci Am. 1996 Jan-Feb;2(1):15. PMID: 9166468.
