Description
INCB018424isaninhibitorofJAK1/2thatisclinicallyusedtotreatrheumatoidarthritisandmyelofibrosis.INCB018424exhibitsanticancer,anti-inflammatory,andantiviralactivities.Inmyelomacells,INCB018424inhibitscellgrowth.INCB018424alsoinhibitsinvitroinfectionbyHIV-1,HIV-2,andSHIVbypreventingviralreplicationinlymphocytes.InanimalmodelsofCCL4-inducedhepaticinjury,INCB018424preventsinflammationbydecreasingneutrophilandmacrophageinfiltration,suppressingactivationofNF-κB,andlimitingreleaseofTNF-α,IL-10,andIL-1β.
References
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HazemSH,ShakerME,AshamallahSA,etal.ThenovelJanuskinaseinhibitorruxolitinibconfersprotectionagainstcarbontetrachloride-inducedhepatotoxicityviamultiplemechanisms.ChemBiolInteract.2014Sep5;220:116-27.PMID:24973641.
GavegnanoC,DetorioM,MonteroC,etal.RuxolitinibandtofacitinibarepotentandselectiveinhibitorsofHIV-1replicationandvirusreactivationinvitro.AntimicrobAgentsChemother.2014;58(4):1977-86.PMID:24419350.
