Ionomycin is a polyether antibiotic that acts as a Ca2+ ionophore, modulating intracellular Ca2+ signaling to increase cytosolic Ca2+ levels. Ionomycin modulates Ca2+ signaling across many cell types and its depletion of intracellular Ca2+ stores may be linked to the induction of apoptosis.
| Cas No. | 56092-82-1 |
|---|---|
| Purity | ≥98% |
| Formula | C41H70O9 Ca |
| Formula Wt. | 747.07 |
| IUPAC Name | calcium;19,21-dihydroxy-22-[5-[5-(1-hydroxyethyl)-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate |
| Synonym | ATCC 31005 |
| Melting Point | 204-206°C |
| Solubility | Soluble in ethanol to 100mM, DMSO to 25mM.5mg/ml in methanol |
| Appearance | White Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | I5753 MSDS PDF |
|---|---|
| Info Sheet | I5753 Info Sheet PDF |
Müller MS, Obel LF, Waagepetersen HS, et al. Complex actions of ionomycin in cultured cerebellar astrocytes affecting both calcium-induced calcium release and store-operated calcium entry. Neurochem Res. 2013 Jun;38(6):1260-5. PMID: 23519933.
Dedkova EN, Sigova AA, Zinchenko VP. Mechanism of action of calcium ionophores on intact cells: ionophore-resistant cells. Membr Cell Biol. 2000;13(3):357-68. PMID: 10768486
Reynolds JE, Eastman A. Intracellular calcium stores are not required for Bcl-2-mediated protection from apoptosis. J Biol Chem. 1996 Nov 1;271(44):27739-43. PMID: 8910367.
Mason MJ, Grinstein S. Ionomycin activates electrogenic Ca2+ influx in rat thymic lymphocytes. Biochem J. 1993 Nov 15;296 ( Pt 1):33-9. PMID: 8250855.
