Description
IonomycinisapolyetherantibioticthatactsasaCa2+ionophore,modulatingintracellularCa2+signalingtoincreasecytosolicCa2+levels.IonomycinmodulatesCa2+signalingacrossmanycelltypesanditsdepletionofintracellularCa2+storesmaybelinkedtotheinductionofapoptosis.
References
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MasonMJ,GrinsteinS.IonomycinactivateselectrogenicCa2+influxinratthymiclymphocytes.BiochemJ.1993Nov15;296(Pt1):33-9.PMID:8250855.