Description
Isoimperatorin is a furocoumarin compound that exhibits anticancer chemotherapeutic, chemopreventive, anti-inflammatory, and antibacterial activities. In vitro, isoimperatorin induces cell cycle arrest at the G2/M phase and inhibits cell proliferation in melanoma cells; separately, it prevents activation of carcinogens such as PBTA-4 and MelQ. In vivo, isoimperatorin decreases tumor growth and tumor weight when combined with UVA irradiation. In cellular models, this compound decreases expression of ROS and vascular cellular adhesion molecule 1 (VCAM-1), increases expression of PPAR-γ, and inhibits NF-κB-induced phosphorylation of Akt, ERK, and PKC. In other cell lines, isoimperatorin inhibits activity of cyclooxygenase (COX-2), preventing production of leukotriene C4 and degranulation of bone marrow-derived mast cells. Additionally, isoimperatorin exhibits activity against both gram positive and gram negative bacteria.
References
Kimura Y, Sumiyoshi M, Sakanaka M, et al. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25. PMID: 23802687.
Marumoto S, Oda Y, Miyazawa M. Antigenotoxic activity of naturally occurring furanocoumarins. Environ Mol Mutagen. 2011 Oct;52(8):646-57. PMID: 21786339
Moon L, Ha YM, Jang HJ, et al. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways. J Ethnopharmacol. 2011 Jan 27;133(2):336-44. PMID: 20937376.
Widelski J, Popova M, Graikou K, et al. Coumarins from Angelica lucida L.--antibacterial activities. Molecules. 2009 Jul 27;14(8):2729-34. PMID: 19701119.
Tang SY, Wang H, Zhang W, et al. Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action. Chem Res Toxicol. 2008 Dec;21(12):2414-23. PMID: 19548360.
Moon TC, Jin M, Son JK, et al. The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch Pharm Res. 2008 Feb;31(2):210-5. PMID: 18365692.
