Description
JatrorrhizineisanalkaloidcompoundoriginallyfoundinCorydalisandCoptydistubersthatexhibitsanticancer,neuroprotective,anti-parasitic,antioxidative,andgastrointestinalmodulatoryactivities.Jatrorrhizineincreasesexpressionofp21andp27,inducingG0/G1phasecellcyclearrestandinhibitingproliferationinmelanomacells.Inneurons,jatrorrhizinesuppressesamyloid-β(Aβ)-inducedincreasesincaspase3activationandcytochromecrelease,preventingneurotoxicity.Jatrorrhizinealsodisplaysanti-parasiticbenefitagainstPlasmodium,Leishmania,andTrypanosoma.Inneurons,thiscompoundinhibitsH202-induceddecreasesinsuperoxidedismutase(SOD)andhemeoxygenase1(HO-1)andincreasesinlactatedehydrogenase(LDH),malondialdehyde(MDA),andROS.Jatrorrhizineincreasesgastricemptyingandintestinaltransitspeedsinanimalmodelsofpostoperativeileus.Additionally,jatrorrhizineinhibitsacetylcholinesterase(AChE).
References
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