K252c is an aglycone analog of staurosporine that acts as a protein kinase inhibitor, inhibiting PKC and potentially PKA. K252c inhibits proliferation of human cytomegalovirus (CMV) and induces apoptosis in cancer cells, indicating some antiviral and anticancer chemotherapeutic activities.
| Cas No. | 85753-43-1 |
|---|---|
| Purity | ≥98% |
| Formula | C20H13N3O |
| Formula Wt. | 311.34 |
| IUPAC Name | 5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione |
| Solubility | Soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;Insoluble in water, 2-propanol |
| Appearance | White to off white powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | K0023 Info Sheet PDF |
|---|
Liu R, Zhu T, Li D, et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2. Arch Pharm Res. 2007 Mar;30(3):270-4. PMID: 17424930.
Zimmermann A, Wilts H, Lenhardt M, et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 2000 Oct;48(1):49-60. PMID: 11080540.
Fabre S, Prudhomme M, Rapp M. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg Med Chem. 1993 Sep;1(3):193-6. PMID: 8081852.
