K252cisanaglyconeanalogofstaurosporinethatactsasaproteinkinaseinhibitor,inhibitingPKCandpotentiallyPKA.K252cinhibitsproliferationofhumancytomegalovirus(CMV)andinducesapoptosisincancercells,indicatingsomeantiviralandanticancerchemotherapeuticactivities.
| CasNo. | 85753-43-1 |
|---|---|
| Purity | ≥98% |
| Formula | C20H13N3O |
| FormulaWt. | 311.34 |
| IUPACName | 5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione |
| Solubility | Solubleinchloroform,acetonitrile,acetone,dioxane,tetrahydrofuran,pyridine;solubleinethanol,methanol,1-propanol,ethylacetateandn-butanol;Insolubleinwater,2-propanol |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | K0023InfoSheetPDF |
|---|
LiuR,ZhuT,LiD,etal.Twoindolocarbazolealkaloidswithapoptosisactivityfromamarine-derivedactinomyceteZ(2)039-2.ArchPharmRes.2007Mar;30(3):270-4.PMID:17424930.
ZimmermannA,WiltsH,LenhardtM,etal.IndolocarbazolesexhibitstrongantiviralactivityagainsthumancytomegalovirusandarepotentinhibitorsofthepUL97proteinkinase.AntiviralRes.2000Oct;48(1):49-60.PMID:11080540.
FabreS,PrudhommeM,RappM.ProteinkinaseCinhibitors;structure-activityrelationshipsinK252c-relatedcompounds.BioorgMedChem.1993Sep;1(3):193-6.PMID:8081852.
