KanamycinBisanaminoglycosideantibioticthatbindsthebacterial16srRNAsubunit,inhibitingtranslocationanddegrADIngtargetRNA;itdisplaysantibacterialefficacyagainstgramnegativebacteria.Kanamycinalsoinhibitsformationoftheinitiationcomplex.Incardiacpacemakercells,kanamycinBdecreasesactionpotentialamplitude,blockingslowCa2+currentsandmodulatingoutwardK+currents.KanamycinBalsoinhibitsmammalianRNAsplicing.
| CasNo. | 4696-76-8 |
|---|---|
| Purity | ≥98% |
| Formula | C18H37N5O10 |
| FormulaWt. | 483.51 |
| ChemicalName | O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,6-dideoxy-alpha-D-gluco-pyranosyl-(1-6))-2-deoxy-D-Streptamine |
| IUPACName | (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4-diol |
| Synonym | Bekanamycin;NK-1006;NEBramycinV. |
| MeltingPoint | 178-182°C(dec) |
| Solubility | Solubleinwaterorformamide.Slightlysolubleinchloroform,isopropylalcohol. |
| Appearance | AlmostWhiteCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | K0054InfoSheetPDF |
|---|
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AukemaKG,ChohanKK,PlourdeGL,etal.Smallmoleculeinhibitorsofyeastpre-mRNAsplicing.ACSChemBiol.2009Sep18;4(9):759-68.PMID:19634919.
MoralesMA,CastrillonJL,HernandezDA.Effectsofbekanamycinanddibekacinontheelectricalactivityofcardiacpacemakercells.ArchMedRes.1993Winter;24(4):339-45.PMID:8118157.
