NADIfloxacinisafluoroquinoloneantibioticthatexhibitsantibacterialefficacyagainstbothgrampositiveandgramnegativebacteria;itinhibitsDNAgyraseandisclinicallyusedtotreatacnevulgaris.NadifloxacininhibitsProponibacterium-stimulatedPBMCproductionofIL-12,IFN-γ,andothercytokines.Nadifloxacinalsodecreasesproductionofoxidativeradicalsbyneutrophils.
| CasNo. | 124858-35-1 |
|---|---|
| Purity | ≥98% |
| Formula | C19H21FN2O4 |
| FormulaWt. | 360.38 |
| ChemicalName | (+-)-9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylicacid |
| Synonym | Jinofloxacin;Acuatim |
| MeltingPoint | 245-247°C |
| Solubility | SolubleinDMSO. |
| Appearance | Paleyelloworyellowcrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | N0114MSDSPDF |
|---|---|
| InfoSheet | N0114InfoSheetPDF |
TakenakaY,HayashiN,TakedaM,etal.GlycolicacidchemicalpeelingimprovesinflammatoryacneeruptionsthroughitsinhibitoryandbactericidaleffectsonPropionibacteriumacnes.JDermatol.2012Apr;39(4):350-4.PMID:21950544.
KuwaharaK,KitazawaT,KitagakiH,etal.Nadifloxacin,anantiacnequinoloneantimicrobial,inhibitstheproductionofproinflammatorycytokinesbyhumanperipheralbloodmononuclearcellsandnormalhumankeratinocytes.JDermatolSci.2005Apr;38(1):47-55.PMID:15795123.
AkamatsuH,SasakiH,KurokawaI,etal.Effectofnadifloxacinonneutrophilfunctions.JIntMedRes.1995Jan-Feb;23(1):19-26.PMID:7774755.
