Description
NatamycinisapolyenemacrolidefoundinStreptomycesnatalensisthatexhibitsantifungalandimmunostimulatoryactivities;thiscompoundbindsergosterol,inhibitingmembranefusion.Natamycinisanantimicrobialcompoundthatisclinicallyusedtotreatkeratitis,displayinggreatefficacyagainstAspergillusandFusarium.NatamycinincreasesactivationoftheNALP3inflammasomeandsecretionofIL-1βbyinducingK+effluxindendriticcells;italsoactivatespolyclonalBcellsinmouselymphocytes.Additionally,natamycinisusedtoimprovetheshelflifeofcheese.
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