LKT/硫酸新霉素/N1755/1克-免疫在线蚂蚁淘旗下平台

商品详细LKT/硫酸新霉素/N1755/1克

LKT/硫酸新霉素/N1755/1克

商品编号： N1755-1g

品牌： lktlabs

市场价： ¥400.00

美元价： 240.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDN1755

CasNo.1405-10-3

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Neomycinisapolycationicaminoglycosideantibioticthatexhibitsantibacterialandneuromodulatoryactivities;itwasoriginallyfoundinspeciesofStreptomyces.Neomycinbindsto23SrRNA,constrainingtRNAintheP-site,inhibitingtranslocationandribosomalrecycling;together,thisresultsininhibitionofproteinsynthesis.NeomycinBbindsandinhibitsbacterialRNasePandbacterialTboxantiterminatorRNA.NeomycinBinhibitsmammalianRNAsplicingaswell.Neomycinalsononcompetitivelyinhibitscationchannels,includingP2Xreceptorsandtransientreceptorpotentialvanilloidreceptor1(TRPV1)channels.Additionally,thiscompoundinhibitsCa2+influx,preventingpresynapticreleaseofacetylcholineandnorepinephrineinfelinesuperiorcervicalganglia.

ProductInfo

CasNo.	1405-10-3
Purity	≥98%
Formula	C₂₃H₄₆N₆O₁₃•H₂SO₄
FormulaWt.	908.9
IUPACName	5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[4-[3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuricacid
Solubility	Solubleinwater(1g/mL).
Appearance	off-whitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	N1755MSDSPDF
InfoSheet	N1755InfoSheetPDF

References

WangL,PulkA,WassermanMR,etal.Allostericcontroloftheribosomebysmall-moleculeantibiotics.NatStructMolBiol.2012Sep;19(9):957-63.PMID:22902368.

BongartzEV,RettingerJ,HausmannR.AminoglycosideblockofP2X2receptorsheterologouslyexpressedinXenopuslaevisoocytes.PurinergicSignal.2010Dec;6(4):393-403.PMID:21437010.

AukemaKG,ChohanKK,PlourdeGL,etal.Smallmoleculeinhibitorsofyeastpre-mRNAsplicing.ACSChemBiol.2009Sep18;4(9):759-68.PMID:19634919.

AnupamR,DenapoliL,MuchenditsiA,etal.IdentificationofneomycinB-bindingsiteinTboxantiterminatormodelRNA.BioorgMedChem.2008Apr15;16(8):4466-70.PMID:18329274.

KawamotoSA,SudhaharCG,HatfieldCL,etal.StudiesonthemechanismofinhibitionofbacterialribonucleasePbyaminoglycosidederivatives.NucleicAcidsRes.2008Feb;36(2):697-704.PMID:18084035.

RaisinghaniM,PremkumarLS.Blockofnativeandclonedvanilloidreceptor1(TRPV1)byaminoglycosideantibiotics.Pain.2005Jan;113(1-2):123-33.PMID:15621372.

WrightJM,CollierB.Theeffectsofneomycinupontransmitterreleaseandaction.JPharmacolExpTher.1977Mar;200(3):576-87.PMID:191590.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂