Netilmicin is an aminoglycoside antibiotic that displays activity against both gram positive and gram negative bacteria, although it is most effective against gram negative bacteria. Netilmicin binds 16s rRNA of the bacterial 30S ribosome, inhibiting translation and tRNA translocation. Netilmicin also decreases melanocyte viability, tyrosinase activity, and melanin production in vitro.
| Cas No. | 56391-57-2 |
|---|---|
| Purity | ≥98% |
| Formula | (C21H41N5O7)2 • 5H2SO4 |
| Formula Wt. | 1441.56 |
| Chemical Name | O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabino- pyranosyl-(1->6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1->4)]-2-deoxy-N1-ethyl-D-streptamine sulfate |
| IUPAC Name | (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4-amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid |
| Synonym | Certomycin; Netilyn; Netromycin; Nettacin; Zetamicin |
| Solubility | Soluble in water. |
| Appearance | White to Yellowish-white Crystalline Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | N1976 MSDS PDF |
|---|---|
| Info Sheet | N1976 Info Sheet PDF |
Wrześniok D, Beberok A, Otreba M, et al. Netilmicin-induced modulation of melanogenesis in HEMa-LP melanocytes. Acta Pol Pharm. 2013 Sep-Oct;70(5):803-8. PMID: 24147358.
Liu TX, Xue XD, Wei LH, et al. Study of plasmid-mediated 16S rRNA methylase genes and drug-resistant transferability of Acinetobacter baumannii isolated from burn ward. Zhonghua Shao Shang Za Zhi. 2009 Apr;25(2):98-102. PMID: 19799032.
