Kendomycinisacytotoxicmacrolideantibioticthatexhibitsantibacterialandanticanceractivities.Kendomycininducesdepolarizationofthemitochondrialmembranepotentialandactivatescaspase3,inducingapoptosisinlymphomacells.KendomycininhibitstheproteasomeandalsobindsBcl-xl.KendomycinisalsoanantagoNISTatendothelinreceptors.
| CasNo. | 183202-73-5 |
|---|---|
| Purity | ≥98% |
| Formula | C29H42O6 |
| FormulaWt. | 486.64 |
| Synonym | (−)-TAN2162 |
| Solubility | SolubleinDMSOormethanol. |
| Appearance | Yellowpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | K1653MSDSPDF |
|---|---|
| InfoSheet | K1653InfoSheetPDF |
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ElnakadyYA,RohdeM,SasseF,etal.EvidenceforthemodeofactionofthehighlycytotoxicStreptomycespolyketidekendomycin.Chembiochem.2007Jul23;8(11):1261-72.PMID:17592829.
