Lactoferrinisanendogenousglycoproteinfoundinsecretoryfluids;itbindsthelactoferrinreceptor.Lactoferrinexhibitsantibacterial,antifungal,antiviral,anti-metastatic,andchemopreventiveactivities.ThiscompoundbindsDNAandinhibitscarcinogenesisinseveralcancerdevelopmentmodels.Additionally,lactoferrindisplaysparticulareffectiveinhibitionofgramnegativebacteria,Candida,rotavirus,herpesvirus,HIV,andcytomegalovirus(CMV).
| CasNo. | 146897-68-9 |
|---|---|
| Purity | ≥92% |
| FormulaWt. | 90kDa |
| Synonym | Lactotransferrin |
| Solubility | Solubleinwater(2%w/v). |
| Appearance | Lightpink-redpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | L0209MSDSPDF |
|---|---|
| InfoSheet | L0209InfoSheetPDF |
FarnaudS,EvansRW.Lactoferrin--amultifunctionalproteinwithantimicrobialproperties.MolImmunol.2003Nov;40(7):395-405.PMID:14568385.
Viejo-DíazM,AndrésMT,FierroJF.ModulationofinvitrofungicidalactivityofhumanlactoferrinagainstCandidaalbicansbyextracellularcationconcentrationandtargetcellmetabolicactivity.AntimicrobAgentsChemother.2004Apr;48(4):1242-8.PMID:15047526.
TsudaH,SekineK,FujitaK,etal.Cancerpreventionbybovinelactoferrinandunderlyingmechanisms--areviewofexperimentalandclinicalstudies.BiochemCellBiol.2002;80(1):131-6.PMID:11908637.
vanderStrateBW,BeljaarsL,MolemaG,etal.Antiviralactivitiesoflactoferrin.AntiviralRes.2001Dec;52(3):225-39.PMID:11675140.
XanthouM.Immuneprotectionofhumanmilk.BiolNeonate.1998;74(2):121-33.PMID:9691154.
HarmsenMC,SwartPJ,deBéthuneMP,etal.Antiviraleffectsofplasmaandmilkproteins:lactoferrinshowspotentactivityagainstbothhumanimmunodeficiencyvirusandhumancytomegalovirusreplicationinvitro.JInfectDis.1995Aug;172(2):380-8.PMID:7622881.
BennettRM,DavisJ.Lactoferrininteractswithdeoxyribonucleicacid:apreferentialreactivitywithdouble-strandedDNAanddissociationofDNA-anti-DNAcomplexes.JLabClinMed.1982Jan;99(1):127-38.PMID:6274982.
