Lactoferrin is an endogenous glycoprotein found in secretory fluids; it binds the lactoferrin receptor. Lactoferrin exhibits antibacterial, antifungal, antiviral, anti-metastatic, and chemopreventive activities. This compound binds DNA and inhibits carcinogenesis in several cancer development models. Additionally, lactoferrin displays particular effective inhibition of gram negative bacteria, Candida, rotavirus, herpesvirus, HIV, and cytomegalovirus (CMV).
| Cas No. | 146897-68-9 |
|---|---|
| Purity | ≥92% |
| Formula Wt. | 90 kDa |
| Synonym | Lactotransferrin |
| Solubility | Soluble in water (2% w/v). |
| Appearance | Light pink-red powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | L0209 MSDS PDF |
|---|---|
| Info Sheet | L0209 Info Sheet PDF |
Farnaud S, Evans RW. Lactoferrin--a multifunctional protein with antimicrobial properties. Mol Immunol. 2003 Nov;40(7):395-405. PMID: 14568385.
Viejo-Díaz M, Andrés MT, Fierro JF. Modulation of in vitro fungicidal activity of human lactoferrin against Candida albicans by extracellular cation concentration and target cell metabolic activity. Antimicrob Agents Chemother. 2004 Apr;48(4):1242-8. PMID: 15047526.
Tsuda H, Sekine K, Fujita K, et al. Cancer prevention by bovine lactoferrin and underlying mechanisms--a review of experimental and clinical studies. Biochem Cell Biol. 2002;80(1):131-6. PMID: 11908637.
van der Strate BW, Beljaars L, Molema G, et al. Antiviral activities of lactoferrin. Antiviral Res. 2001 Dec;52(3):225-39. PMID: 11675140.
Xanthou M. Immune protection of human milk. Biol Neonate. 1998;74(2):121-33. PMID: 9691154.
Harmsen MC, Swart PJ, de Béthune MP, et al. Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. J Infect Dis. 1995 Aug;172(2):380-8. PMID: 7622881.
Bennett RM, Davis J. Lactoferrin interacts with deoxyribonucleic acid: a preferential reactivity with double-stranded DNA and dissociation of DNA-anti-DNA complexes. J Lab Clin Med. 1982 Jan;99(1):127-38. PMID: 6274982.
