LamivudineisanantiviralcompoundclinicallyusedasatreatmentforhepatitisBinfection;itactsasathymidineanalog,inhibitingthereversetranscriptaseenzyme.Intwoseparateinvitromodels,lamivudinedecreasedHIVproductioninrecentlyinfectedrestingcellsandinhibitedgrowthofHIV-infectedcellsatlowconcentrations.Additionally,lamivudineincreasesinsulinresistancewhengivenwithzidovudineinclinicalsettings.
| CasNo. | 134678-17-4 |
|---|---|
| Purity | ≥98% |
| Formula | C8H11N3O3S |
| FormulaWt. | 229.26 |
| IUPACName | 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one |
| Synonym | Epivir |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | L0350InfoSheetPDF |
|---|---|
| Brochures | AntiviralsBooklet |
BlümerRM,vanVonderenMG,SutinenJ,etal.Zidovudine/lamivudinecontributestoinsulinresistancewithin3monthsofstartingcombinationantiretroviraltherapy.AIDS.2008Jan11;22(2):227-36.PMID:18097225.
Saavedra-LozanoJ,McCoigCC,CaoY,etal.Zidovudine,lamivudine,andabacavirhavedifferenteffectsonrestingcellsinfectedwithhumanimmunodeficiencyvirusinvitro.AntimicrobAgentsChemother.2004Aug;48(8):2825-30.PMID:15273087
BalestrieriE,ForteG,MatteucciC,etal.EffectoflamivudineontransmissionofhumanT-celllymphotropicvirustype1toadultperipheralbloodmononuclearcellsinvitro.AntimicrobAgentsChemother.2002Sep;46(9):3080-3.PMID:12183277.
