LKT/LEFLUNOMIDE/L1817/500 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/LEFLUNOMIDE/L1817/500 mg

LKT/LEFLUNOMIDE/L1817/500 mg

商品编号： L1817-500mg

品牌： lktlabs

市场价： ¥4940.00

美元价： 2964.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDL1817

CasNo.75706-12-6

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Leflunomideinhibitsdihydroorotatedehydrogenase,preventingUMPformationandpyrimidinesynthesis.MetabolitesofleflunomidemayinhibitvariouskinasessuchasJNKandJAK.Leflunomideisclinicallyusedtotreatrheumatoidarthritis;itexhibitsimmunosuppressive,antiviral,andanticanceractivities.Inseveralcellularmodels,leflunomidepreventsapoptosisandincreasesviABIlityinhumancytomegalovirus(CMV)-infectedcellsandinhibitsreplicationofpolyomavirusBK.Additionally,leflunomideincreasesactivityofarylhydrocarbonreceptors,inhibitingproliferationofmelanomacells.

ProductInfo

CasNo.	75706-12-6
Purity	≥98%
Formula	C₁₂H₉F₃N₂O₂
FormulaWt.	270.21
ChemicalName	5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
IUPACName	5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
Synonym	HWA-486;Arava
MeltingPoint	166.5°C
Solubility	SolubleinDMSOormethanol.
Appearance	Whiteoroff-whitecrystallinepowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	L1817MSDSPDF
InfoSheet	L1817InfoSheetPDF

References

QiR,Hua-SongZ,Xiao-FengZ.Leflunomideinhibitstheapoptosisofhumanembryoniclungfibroblastsinfectedbyhumancytomegalovirus.EurJMedRes.2013Feb1;18:3.PMID:23369524.

O"DonnellEF,KopparapuPR,KochDC,etal.Thearylhydrocarbonreceptormediatesleflunomide-inducedgrowthinhibitionofmelanomacells.PLoSOne.2012;7(7):e40926.PMID:22815870.

BernhoffE,TyldenGD,KjerpesethLJ,etal.LeflunomideinhibitionofBKvirusreplicationinrenaltubularepithelialcells.JVirol.2010Feb;84(4):2150-6.PMID:19955306.

PintoP,DougadosM.Leflunomideinclinicalpractice.ActaReumatolPort.2006Jul-Sep;31(3):215-24.PMID:17094333.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂