LeptomycinisapolyketideantibioticinitiallyproducedbyStreptomyces.Leptomycinexhibitsanticancerandantifungalactivity.LeptomycininhibitsCRM1,preventingnuclearexportofproteins.Inlungcancercells,leptomycininducesG1phasecellcyclearrest;incervicalcarcinomacells,leptomycinincreasesactivationofp53,inducingapoptosis.
| CasNo. | 87081-35-4 |
|---|---|
| Purity | ≥98% |
| Formula | C33H48O6 |
| FormulaWt. | 540.74 |
| ChemicalName | 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-Nonadecapentaenoicacid |
| IUPACName | (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2R,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoicacid |
| Synonym | LMB;Elactocin,CI-940,CL-1957A,NSC-364372,PD-114720. |
| MeltingPoint | 41-44°C |
| Solubility | Solubleinethanolormethanol. |
| Appearance | ClearcolorlesssolutioninabsoluteETOH |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | L1761MSDSPDF |
|---|---|
| InfoSheet | L1761InfoSheetPDF |
SunQ,CarrascoYP,HuY,etal.NuclearexportinhibitionthroughcovalentconjugationandhydrolysisofLeptomycinBbyCRM1.ProcNatlAcadSciUSA.2013Jan22;110(4):1303-8.PMID:23297231.
AbkalloHM,KawanoH,WatanabeK,etal.Anewcell-basedreportersystemforsensitivescreeningofnuclearexportinhibitors.DrugDiscovTher.2011Dec;5(6):286-92.PMID:22466439.
LuC,ShaoC,CobosE,etal.ChemotherapeuticsensitizationofleptomycinBresistantlungcancercellsbypretreatmentwithdoxorubicin.PLoSOne.2012;7(3):e32895.PMID:22412944.
HamamotoT,GunjiS,TsujiH,etal.LeptomycinsAandB,newantifungalantibiotics.I.Taxonomyoftheproducingstrainandtheirfermentation,purificationandcharacterization.JAntibiot(Tokyo).1983Jun;36(6):639-45.PMID:6874585.
