Lomefloxacin is a fluoroquinolone antibiotic that is clinically used to treat respiratory and urinary tract infections; it displays antibacterial efficacy by inhibiting DNA gyrase and topoisomerase IV. Lomefloxacin is primarily active against gram negative aerobic bacteria; it may induce photocleavage of DNA.
| Cas No. | 98079-52-8 |
|---|---|
| Purity | ≥98% |
| Formula | C17H19F2N3O3 • HCl |
| Formula Wt. | 387.81 |
| Chemical Name | 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid monohydrochloride |
| IUPAC Name | 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylicacid;hydrochloride |
| Synonym | Lomefloxacin monohydrochloride; Bareon; Chimono; Lomebact; Maxaquin; Okacyn; Uniquin |
| Melting Point | 290-300(dec.) |
| Appearance | Yellowish, almost white, crystalline powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | L5749 Info Sheet PDF |
|---|
Martínez L, Chignell CF. Photocleavage of DNA by the fluoroquinolone antibacterials. J Photochem Photobiol B. 1998 Aug 21;45(1):51-9. PMID: 9819899.
Just PM. Overview of the fluoroquinolone antibiotics. Pharmacotherapy. 1993 Mar-Apr;13(2 Pt 2):4S-17S. PMID: 8386356.
Symonds WT, Nix DE. Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials. Clin Pharm. 1992 Sep;11(9):753-66. PMID: 1325892.
