Lonidamineinhibitsglycolysisbyinhibitinghexokinases;itexhibitsanti-aging,anti-parasitic,andanti-fertilityactivities.LonidamineincreasesLifespaninCaenorhaBDitiselegans,increasingstressresistanceandpromotingmitochondrialrespirationbyincreasinglevelsofROS.Lonidaminealsodisplaysantibioticactivity,causingdeathinTrypanosoma.Invivo,lonidamineincreasestestesweightanddecreasesspermcountandtestosteronelevels.
| CasNo. | 50264-69-2 |
|---|---|
| Purity | ≥98% |
| Formula | C15H10Cl2N2O2 |
| FormulaWt. | 321.16 |
| ChemicalName | 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylicacid |
| IUPACName | 1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylicacid |
| Synonym | Diclondazolicacid;DICA;AF-1890;Doridamina. |
| MeltingPoint | 207°C |
| Solubility | Solubleinmethanoloraceticacid. |
| Appearance | Whiteoroff-whitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | L5658InfoSheetPDF |
|---|
SchmeisserS,ZarseK,RistowM.LonidamineextendslifespanofadultCaenorhabditiselegansbyincreasingtheformationofmitochondrialreactiveoxygenspecies.HormMetabRes.2011Sep;43(10):687-92.PMID:21932172.
ChambersJW,FowlerML,MorrisMT,etal.Theanti-trypanosomalagentlonidamineinhibitsTrypanosomabruceihexokinase1.MolBiochemParasitol.2008Apr;158(2):202-7.PMID:18262292.
TrainaME,GuarinoM,NatoliA,etal.Lonidamineaffectstesticularsteroidhormonesinimmaturemice.ToxicolApplPharmacol.2007May15;221(1):95-101.PMID:17442358.
DitonnoP,BattagliaM,SelvaggioO,etal.ClinicalEvidenceSupportingtheRoleofLonidaminefortheTreatmentofBPH.RevUrol.2005;7Suppl7:S27-33.PMID:16986058.
