Description
Magainin 1 is a membrane-disruptive antimicrobial/antibacterial peptide (AMP) initially produced by African frogs. Magainin 1 exhibits antibacterial activity, inhibiting growth of gram positive bacteria by forming ion channels in bacterial membranes and altering membrane permeability; this prevents bacterial adhesion to membranes and inhibits bacterial growth. Magainin 1 also displays potential anticancer benefit in mammalian leukemia cells, increasing levels of ROS and release of cytochrome c and inducing apoptosis.
References
Humblot V, Yala JF, Thebault P, et al. The antibacterial activity of Magainin I immobilized onto mixed thiols Self-Assembled Monolayers. Biomaterials. 2009 Jul;30(21):3503-12. PMID: 19345992.
Cruz-Chamorro L, Puertollano MA, Puertollano E, et al. In vitro biological activities of magainin alone or in combination with nisin. Peptides. 2006 Jun;27(6):1201-9. PMID: 16356589.
Mozsolits H, Wirth HJ, Werkmeister J, et al. Analysis of antimicrobial peptide interactions with hybrid bilayer membrane systems using surface plasmon resonance. Biochim Biophys Acta. 2001 May 2;1512(1):64-76. PMID: 11334625.
Matsuzaki K. Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes. Biochim Biophys Acta. 1999 Dec 15;1462(1-2):1-10. PMID: 10590299.
Cruciani RA, Barker JL, Durell SR, et al. Magainin 2, a natural antibiotic from frog skin, forms ion channels in lipid bilayer membranes.
