Magainin 2 is a membrane-disruptive antimicrobial/antibacterial peptide (AMP). Magainin 2 binds to gangliosides on cell membranes, increases membrane permeability by forming pores. Magainin 2 induces formation of giant unilamellar vesicles in lipid membranes, inducing membrane leakage and inhibiting bacterial growth.
| Cas No. | 108433-95-0 |
|---|---|
| Purity | ≥95% |
| Formula | C114H180N30O29S |
| Formula Wt. | 2466.95 |
| Synonym | Z-12 Peptide, Mag-2 |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | M0126 MSDS PDF |
|---|---|
| Info Sheet | M0126 Info Sheet PDF |
Last NB, Miranker AD. Common mechanism unites membrane poration by amyloid and antimicrobial peptides. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6382-7. PMID: 23576726.
Miyazaki Y, Aoki M, Yano Y, et al. Interaction of antimicrobial peptide magainin 2 with gangliosides as a target for human cell binding. Biochemistry. 2012 Dec 21;51(51):10229-35. PMID: 23194027.
Tamba Y, Ariyama H, Levadny V, et al. Kinetic pathway of antimicrobial peptide magainin 2-induced pore formation in lipid membranes. J Phys Chem B. 2010 Sep 23;114(37):12018-26. PMID: 20799752.
